Ensemble-based design of tau to inhibit aggregation while preserving biological activity.

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作者： Sofia,Bali ^[1] ; Ruhar,Singh ^[2] ; Pawel M,Wydorski ^[2] ; Aleksandra,Wosztyl ^[1] ; Valerie A,Perez ^[2] ; Dailu,Chen ^[1] ; Josep,Rizo ^[2] ; Lukasz A,Joachimiak ^[2]

作者单位： Molecular Biophysics Graduate Program, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States. ^[1] Center for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas. ^[2] Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States Southwestern Medical Center, Dallas, TX 75390, United States. ^[3] Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States. ^[4] Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States. ^[5]

DOI 10.21203/rs.3.rs-3796916/v1

PMID 38313287

发布时间 2024-02-12

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