Computational evidences of a misfolding event in an aggregation-prone light chain preceding the formation of the non-native pathogenic dimer.
第一作者:
Fausta,Desantis
第一单位:
The Open University Affiliated Research Centre at Istituto Italiano di Tecnologia, Genova, Italy.
作者:
主题词
人类(Humans);分子动力学模拟(Molecular Dynamics Simulation);蛋白质多聚化(Protein Multimerization);蛋白质折叠(Protein Folding);免疫球蛋白轻链(Immunoglobulin Light Chains);亲水和疏水相互作用(Hydrophobic and Hydrophilic Interactions);突变(Mutation);蛋白质相互作用域和基序(Protein Interaction Domains and Motifs)
DOI
10.1002/prot.26672
PMID
38314653
发布时间
2024-06-03
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Proteins
797-807页
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