Synthesis and biological evaluation of 1H-pyrrolo[3,2-g]isoquinolines.

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第一作者： Mathilde,Defois

第一单位： Université Clermont Auvergne, CNRS, Clermont Auvergne INP, ICCF, F-63000 Clermont-Ferrand, France.

作者： Mathilde,Defois ^[1] ; Béatrice,Josselin ^[2] ; Pierre,Brindeau ^[3] ; Andreas,Krämer ^[4] ; Stefan,Knapp ^[4] ; Fabrice,Anizon ^[1] ; Francis,Giraud ^[5] ; Sandrine,Ruchaud ^[6] ; Pascale,Moreau ^[7]

作者单位： Université Clermont Auvergne, CNRS, Clermont Auvergne INP, ICCF, F-63000 Clermont-Ferrand, France. ^[1] Sorbonne Université, CNRS, UMR8227, Integrative Biology of Marine Models Laboratory (LBI2M), Station Biologique de Roscoff, 29680 Roscoff, France; Sorbonne Université, CNRS, FR2424, Plateforme de criblage KISSf (Kinase Inhibitor Specialized Screening facility), Station Biologique de Roscoff, 29680 Roscoff, France. ^[2] Sorbonne Université, CNRS, UMR8227, Integrative Biology of Marine Models Laboratory (LBI2M), Station Biologique de Roscoff, 29680 Roscoff, France. ^[3] Institute of Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany; Frankfurt Cancer Institute, Goethe University, Frankfurt am Main, Germany. ^[4] Université Clermont Auvergne, CNRS, Clermont Auvergne INP, ICCF, F-63000 Clermont-Ferrand, France. Electronic address: francis.giraud@uca.fr. ^[5] Sorbonne Université, CNRS, UMR8227, Integrative Biology of Marine Models Laboratory (LBI2M), Station Biologique de Roscoff, 29680 Roscoff, France. Electronic address: sruchaud@sb-roscoff.fr. ^[6] Université Clermont Auvergne, CNRS, Clermont Auvergne INP, ICCF, F-63000 Clermont-Ferrand, France. Electronic address: pascale.moreau@uca.fr. ^[7]

关键词 Cellular activity Haspin Indoles Isoquinolines Kinase inhibition Pyrroles

主题词蛋白激酶抑制剂(Protein Kinase Inhibitors);吡咯类(Pyrroles);构效关系(Structure-Activity Relationship);异喹啉类(Isoquinolines)

DOI 10.1016/j.bmc.2024.117619

PMID 38320389

发布时间 2024-02-23

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