Unravelling pH/pKa influence on pH-responsive drug carriers: Insights from ibuprofen-silica interactions and comparative analysis with carbon nanotubes, sulfasalazine, and alendronate.

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作者： Marriam,Yamin ^[1] ; Zafar Khan,Ghouri ^[2] ; Nashiour,Rohman ^[3] ; Junaid Ali,Syed ^[4] ; Adam,Skelton ^[5] ; Khalid,Ahmed ^[6]

作者单位： Department of Biosciences, Salim Habib University, Karachi, Pakistan. ^[1] L. E. J. Nanotechnology Centre, H. E. J. Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan; Net Zero Industry Innovation Centre, Teesside University, Middlesbrough, Tees Valley TS1 3BX, UK. ^[2] Department of Chemistry, College of Science, Sultan Qaboos University, P. O. Box 36, Al-khoudh, Muscat P. C. 123, Oman. ^[3] L. E. J. Nanotechnology Centre, H. E. J. Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan. ^[4] Department of Pharmaceutical Sciences, University of KwaZulu-Natal, Durban, 4000, South Africa. Electronic address: dradamskelton@gmail.com. ^[5] L. E. J. Nanotechnology Centre, H. E. J. Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan. Electronic address: khalid.ahmed@iccs.edu. ^[6]

关键词 Carboxylated carbon nanotube Density functional theory Drug delivery Ibuprofen Mesoporous silica nanoparticles pH-dependent