Human β-Defensin 3 Inhibition of <i>P. gingivalis</i> LPS-Induced IL-1β Production by BV-2 Microglia through Suppression of Cathepsins B and L.

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作者： Erika,Inoue ^[1] ; Shiyo,Minatozaki ^[1] ; Sachi,Shimizu ^[1] ; Sayaka,Miyamoto ^[1] ; Misato,Jo ^[1] ; Junjun,Ni ^[2] ; Hidetoshi,Tozaki-Saitoh ^[3] ; Kosuke,Oda ^[4] ; Saori,Nonaka ^[4] ; Hiroshi,Nakanishi ^[4]

作者单位： Faculty of Pharmacy, Yasuda Women's University, Hiroshima 731-0153, Japan. ^[1] Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing 100081, China. ^[2] Department of Pharmaceutical Sciences, School of Pharmacy at Fukuoka, International University of Health and Welfare, Okawa 831-8501, Japan. ^[3] Department of Pharmacology, Faculty of Pharmacy, Yasuda Women's University, Yasuhigashi, Hiroshima 731-0153, Japan. ^[4]

关键词 BV-2 microglia CA-074Me Porphyromonas gingivalis cathepsin B human β-defensin 3 interleukin-1β lipopolysaccharide nuclear factor-κB outer membrane vesicles

主题词人类(Humans);β防御素(beta-Defensins);组织蛋白酶B(Cathepsin B);I-κB激酶(I-kappa B Kinase);炎性体(Inflammasomes);白细胞介素1β(Interleukin-1beta);脂多糖类(Lipopolysaccharides);小神经胶质细胞(Microglia);NF-κB(NF-kappa B);毒力因子类(Virulence Factors)

DOI 10.3390/cells13030283

PMID 38334675

发布时间 2025-01-15

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2024年13卷3期

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Human β-Defensin 3 Inhibition of <i>P. gingivalis</i> LPS-Induced IL-1β Production by BV-2 Microglia through Suppression of Cathepsins B and L.

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Human β-Defensin 3 Inhibition of <i>P. gingivalis</i> LPS-Induced IL-1β Production by BV-2 Microglia through Suppression of Cathepsins B and L.

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