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Predicting multimodal chromatography of therapeutic antibodies using multiscale modeling.

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第一作者： Rudger,Hess

第一单位： Karlsruhe Institute of Technology (KIT), Institute of Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe, Germany; DSP Development, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany.

作者： Rudger,Hess ^[1] ; Jan,Faessler ^[2] ; Doil,Yun ^[2] ; Ahmed,Mama ^[2] ; David,Saleh ^[2] ; Jan-Hendrik,Grosch ^[2] ; Gang,Wang ^[2] ; Thomas,Schwab ^[2] ; Jürgen,Hubbuch ^[3]

作者单位： Karlsruhe Institute of Technology (KIT), Institute of Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe, Germany; DSP Development, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany. ^[1] DSP Development, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany. ^[2] Karlsruhe Institute of Technology (KIT), Institute of Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe, Germany. Electronic address: juergen.hubbuch@kit.edu. ^[3]

关键词 In silico / a priori process development Mechanistic chromatography modeling Mixed-mode antibody descriptors Multispecific monoclonal antibody (mAb) formats Quantitative structure-activity/property relationship (QSAR/QSPR)

医学主题词色谱法, 离子交换(Chromatography, Ion Exchange);量化构效关系(Quantitative Structure-Activity Relationship);抗体(Antibodies)

DOI 10.1016/j.chroma.2024.464706

PMID 38335881

发布时间 2024-02-27

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