Oral immunization with recombinant L. lactis expressing GCRV-II VP4 produces protection against grass carp reovirus infection.

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第一作者： Huiliang,Wu

第一单位： College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China; Key Laboratory of Fishery Drug Development, Ministry of Agriculture and Rural Affairs, Guangdong Provincial Key Laboratory of Aquatic Animal Immunology and Sustainable Aquaculture, Pearl River Fishery Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, 510380, China.

作者： Huiliang,Wu ^[1] ; Jiyuan,Yin ^[2] ; Siming,Li ^[3] ; Hao,Wang ^[4] ; Peng,Jiang ^[2] ; Pengfei,Li ^[5] ; Zhaoyang,Ding ^[4] ; Han,Yan ^[3] ; Bo,Chen ^[6] ; Linchuan,Wang ^[7] ; Qing,Wang ^[8]

作者单位： College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China; Key Laboratory of Fishery Drug Development, Ministry of Agriculture and Rural Affairs, Guangdong Provincial Key Laboratory of Aquatic Animal Immunology and Sustainable Aquaculture, Pearl River Fishery Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, 510380, China. ^[1] Key Laboratory of Fishery Drug Development, Ministry of Agriculture and Rural Affairs, Guangdong Provincial Key Laboratory of Aquatic Animal Immunology and Sustainable Aquaculture, Pearl River Fishery Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, 510380, China. ^[2] Institute for Quality & Safety and Standards of Agricultural Products Research, Jiangxi Academy of Agricultural Sciences, Nanlian Road 602, Nanchang, 330200, China. ^[3] Shanghai Ocean University/National Demonstration Center for Experimental Fisheries Science Education, Shanghai, 201306, China. ^[4] Guangxi Key Laboratory of Marine Environmental Science, Guangxi Academy of Sciences, Nanning, 530000, China. ^[5] Nanchang Yimen Biology Technology Co., Ltd., Nanchang, 330200, China. ^[6] College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China. Electronic address: lcwang@scau.edu.cn. ^[7] Key Laboratory of Fishery Drug Development, Ministry of Agriculture and Rural Affairs, Guangdong Provincial Key Laboratory of Aquatic Animal Immunology and Sustainable Aquaculture, Pearl River Fishery Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, 510380, China. Electronic address: wangqing@prfri.ac.cn. ^[8]

关键词 Grass carp reovirus Immunogenicity L. lactis Oral immunization Protective efficacy VP4