首页> Journal of advanced research> DNA hypomethylation-mediated upregulation of GADD45B facilitates airway inflammation and epithelial cell senescence in COPD.

DNA hypomethylation-mediated upregulation of GADD45B facilitates airway inflammation and epithelial cell senescence in COPD.

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第一作者： Yuan,Zhan

第一单位： Department of Respiratory and Critical Care Medicine, National Clinical Research Center of Respiratory Disease, Key Laboratory of Pulmonary Diseases of Health Ministry, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

作者： Yuan,Zhan ^[1] ; Qian,Huang ^[1] ; Zhesong,Deng ^[1] ; Shanshan,Chen ^[1] ; Ruonan,Yang ^[1] ; Jiaheng,Zhang ^[1] ; Yating,Zhang ^[1] ; Maocuo,Peng ^[2] ; Jixing,Wu ^[1] ; Yiya,Gu ^[1] ; Zhilin,Zeng ^[3] ; Jungang,Xie ^[4]

作者单位： Department of Respiratory and Critical Care Medicine, National Clinical Research Center of Respiratory Disease, Key Laboratory of Pulmonary Diseases of Health Ministry, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. ^[1] Department of Respiratory Medicine, Qinghai University Affiliated Hospital, Xining, Qinghai, China. ^[2] Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease, Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address: ulfnssul@sina.com. ^[3] Department of Respiratory and Critical Care Medicine, National Clinical Research Center of Respiratory Disease, Key Laboratory of Pulmonary Diseases of Health Ministry, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address: xiejjgg@tjh.tjmu.edu.cn. ^[4]

关键词 Cellular senescence Chronic obstructive pulmonary disease DNA methylation GADD45B Inflammation