Enhanced Efficiency of Pd(0)-Based Single Chain Polymeric Nanoparticles for <i>in Vitro</i> Prodrug Activation by Modulating the Polymer's Microstructure.

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作者： Linlin,Deng ^[1] ; Anjana,Sathyan ^[2] ; Catherine,Adam ^[1] ; Asier,Unciti-Broceta ^[2] ; Víctor,Sebastian ^[3] ; Anja R A,Palmans ^[3]

作者单位： Laboratory for Macromolecular and Organic Chemistry, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands. ^[1] Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands. ^[2] Edinburgh Cancer Research, Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, United Kingdom. ^[3] Instituto de Nanociencia y Materiales de Aragón (INMA), CSIC-Universidad de Zaragoza, Zaragoza 50009, Spain. ^[4] Department of Chemical and Environmental Engineering, Universidad de Zaragoza, Campus Rio Ebro, 50018 Zaragoza, Spain. ^[5] Laboratorio de Microscopías Avanzadas, Universidad de Zaragoza, 50018 Zaragoza, Spain. ^[6] Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28029 Madrid, Spain. ^[7]

关键词 bioorthogonal catalysis compartmentalization in vitro catalysis nanocatalyst prodrug activation single chain polymeric nanoparticle

主题词人类(Humans);药物前体(Prodrugs);抗肿瘤药(Antineoplastic Agents);纳米粒子(Nanoparticles);聚合物(Polymers);Hep G2细胞(Hep G2 Cells);催化作用(Catalysis)

DOI 10.1021/acs.nanolett.3c04466

PMID 38346395

发布时间 2024-02-25

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