Free total rhubarb anthraquinones protect intestinal mucosal barrier of SAP rats via inhibiting the NLRP3/caspase-1/GSDMD pyroptotic pathway.

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作者： Yue,Zeng ^[1] ; Xingyu,Liu ^[2] ; Qing,Yi ^[2] ; Gan,Qiao ^[2] ; Lulu,Wang ^[2] ; Li,Chen ^[3] ; Ling,Fan ^[4] ; Yao,Li ^[2] ; Lingjing,Duan ^[2] ; Liqiang,Huang ^[5] ; Qian,Zhuang ^[2] ; Yejiang,Zhou ^[6] ; Yuxia,Xiong ^[7]

作者单位： Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, China; Department of Pharmacy, People's Hospital of Zhongjiang County, Deyang, Sichuan, 618000, China. ^[1] Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, China. ^[2] Department of Pharmacy, Affiliated Hospital of Traditional Chinese Medicine, Southwest Medical University, Luzhou, Sichuan, 646000, China. ^[3] Department of Pharmacy, People's Hospital of Ya'an, Ya'an, 625000, China. ^[4] Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, China; Department of Pharmacy, Second People's Hospital of Yibin, Yibin, 644000, China. ^[5] Department of Gastrointestinal Surgery, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, China. Electronic address: zyj7525@163.com. ^[6] Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, China. Electronic address: xyx_cell@swmu.edu.cn. ^[7]

关键词 Free total rhubarb anthraquinones Intestinal immunity Intestinal mucosal barrier Pyroptosis Severe acute pancreatitis