换一批
换一批Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src.
作者：
Zhenxi,Li [1]
;
Xinghai,Yang [2]
;
Ruifeng,Fu [3]
;
Zhipeng,Wu [2]
;
Shengzhao,Xu [4]
;
Jian,Jiao [2]
;
Ming,Qian [2]
;
Long,Zhang [5]
;
Chunbiao,Wu [3]
;
Tianying,Xie [3]
;
Jiqiang,Yao [2]
;
Zhixiang,Wu [2]
;
Wenjun,Li [4]
;
Guoli,Ma [4]
;
Yu,You [4]
;
Yihua,Chen [4]
;
Han-Kun,Zhang [4]
;
Yiyun,Cheng [4]
;
Xiaolong,Tang [6]
;
Pengfei,Wu [7]
;
Gewei,Lian [7]
;
Haifeng,Wei [2]
;
Jian,Zhao [2]
;
Jianrong,Xu [8]
;
Lianzhong,Ai [5]
;
Stefan,Siwko [9]
;
Yue,Wang [10]
;
Jin,Ding [11]
;
Gaojie,Song [12]
;
Jian,Luo [13]
;
Mingyao,Liu [14]
;
Jianru,Xiao [15]
作者单位：
Institute of Orthopedic Biomedical and Device Innovation, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China. zxli@usst.edu.cn.;Institute of Orthopedics, Department of Orthopedic Oncology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, 200003, China. zxli@usst.edu.cn.;East China Normal University and Shanghai Changzheng Hospital Joint Research Center for Orthopedic Oncology, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China. zxli@usst.edu.cn.;Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA. zxli@usst.edu.cn.
[1]
Institute of Orthopedics, Department of Orthopedic Oncology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, 200003, China.
[2]
Institute of Orthopedic Biomedical and Device Innovation, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China.;Institute of Orthopedics, Department of Orthopedic Oncology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, 200003, China.
[3]
East China Normal University and Shanghai Changzheng Hospital Joint Research Center for Orthopedic Oncology, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.
[4]
Institute of Orthopedic Biomedical and Device Innovation, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China.
[5]
School of Biomedical Sciences, Hunan University, Changsha, 410082, China.
[6]
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.
[7]
Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
[8]
Department of Translational Medical Sciences, Institute of Biosciences and Technology, Texas A&M University Health Science Center, Houston, TX, USA.
[9]
Shanghai Key Lab of Cell Engineering; Translational Medicine Research Center, Naval Medical University, Shanghai, 200433, China.
[10]
Clinical Cancer Institute, Center for Translational Medicine, Naval Medical University, Shanghai, 200433, China.
[11]
East China Normal University and Shanghai Changzheng Hospital Joint Research Center for Orthopedic Oncology, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China. gjsong@bio.ecnu.edu.cn.
[12]
Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Tongji University School of Medicine, Shanghai, China. jluo@tongji.edu.cn.
[13]
East China Normal University and Shanghai Changzheng Hospital Joint Research Center for Orthopedic Oncology, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China. myliu@bio.ecnu.edu.cn.
[14]
Institute of Orthopedic Biomedical and Device Innovation, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China. jianruxiao83@163.com.;Institute of Orthopedics, Department of Orthopedic Oncology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, 200003, China. jianruxiao83@163.com.;East China Normal University and Shanghai Changzheng Hospital Joint Research Center for Orthopedic Oncology, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China. jianruxiao83@163.com.
[15]
主题词
动物(Animals);小鼠(Mice);破骨细胞(Osteoclasts);受体, G-蛋白偶联(Receptors, G-Protein-Coupled);src族激酶类(src-Family Kinases);小鼠, 基因敲除(Mice, Knockout);骨质吸收(Bone Resorption)
DOI
10.1038/s41467-024-44852-9
PMID
38346942
发布时间
2025-01-04
- 浏览1
Nature communications
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