Serial passage of PDCoV in cell culture reduces its pathogenicity and its damage of gut microbiota homeostasis in piglets.

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作者： Yunfei,Zhang ^[1] ; Lulu,Si ^[1] ; Junlong,Gao ^[1] ; Xiangli,Shu ^[1] ; Congrui,Qiu ^[1] ; Yue,Zhang ^[1] ; Shaopo,Zu ^[2] ; Hui,Hu ^[1]

作者单位： The College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, China. ^[1] Key Laboratory for Animal-derived Food Safety of Henan Province, Zhengzhou, Henan, China. ^[2] Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, Zhengzhou, Henan, China. ^[3]

关键词 genetic variation gut microbiota pathogenicity porcine deltacoronavirus (PDCoV)serial passage

主题词动物(Animals);猪(Swine);毒力(Virulence);连续传代(Serial Passage);猪疾病(Swine Diseases);细胞培养技术(Cell Culture Techniques);腹泻(Diarrhea);疫苗(Vaccines);内环境稳定(Homeostasis)

DOI 10.1128/msystems.01346-23

PMID 38349151

发布时间 2024-03-21

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2024年9卷3期

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Serial passage of PDCoV in cell culture reduces its pathogenicity and its damage of gut microbiota homeostasis in piglets.

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Serial passage of PDCoV in cell culture reduces its pathogenicity and its damage of gut microbiota homeostasis in piglets.

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