Discovery of a novel series of pyridone amides as Na<sub>V</sub>1.8 inhibitors.

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作者： Yanfang,Wang ^[1] ; Shilong,Hu ^[1] ; Yuhao,Chen ^[1] ; Meiyuan,Chen ^[1] ; Di,Zhang ^[1] ; Wencheng,Liu ^[1] ; Chunxia,Chen ^[1] ; Yu,Gan ^[1] ; Menglan,Luo ^[1] ; Bowen,Ke ^[2]

作者单位： Department of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China. ^[1] Department of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China. Electronic address: bowenke@scu.edu.cn. ^[2]

关键词 Chronic pain Na(V)1.8 Pyridone amides Sodium channel blocker

主题词人类(Humans);酰胺类(Amides);镇痛药(Analgesics);神经痛(Neuralgia);吡啶酮类(Pyridones);钠通道阻滞剂(Sodium Channel Blockers)

DOI 10.1016/j.bmcl.2024.129655

PMID 38350529

发布时间 2025-02-05

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