Discovery of N-(1-(2-hydroxyethyl)quinolin-2-one)-N'-(1-phenyl-1H-pyrazol-5-yl)methyl) urea as Mode-Selective TRPV1 antagonist.

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作者： Dongxu,Zuo ^[1] ; Mannkyu,Hong ^[1] ; Aeran,Jung ^[1] ; Sunho,Lee ^[1] ; Nayeon,Do ^[1] ; Sungwon,Jung ^[1] ; Yubum,Jeon ^[1] ; Ji,Won Jeong ^[1] ; Guocheng,Huang ^[1] ; Li-Xuan,Li ^[1] ; Peter M,Blumberg ^[1] ; Hongryul,Yoon ^[2] ; Yoonji,Lee ^[2] ; Jihyae,Ann ^[3] ; Jeewoo,Lee ^[4]

作者单位： Laboratory of Medicinal Chemistry, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea. ^[1] College of Pharmacy, Chung-Ang University, Seoul 06974, Republic of Korea. ^[2] Laboratory of Medicinal Chemistry, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea. Electronic address: jihuya@gmail.com. ^[3] Laboratory of Medicinal Chemistry, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea. Electronic address: jeewoo@snu.ac.kr. ^[4]

关键词 Analgesic Benzopyridone TRPV1 Antagonist Vanilloid Receptor 1

主题词尿素(Urea);辣椒辣素(Capsaicin);构效关系(Structure-Activity Relationship);模型, 分子(Models, Molecular);吡唑类(Pyrazoles);TRPV阳离子通道(TRPV Cation Channels)

DOI 10.1016/j.bmcl.2024.129656

PMID 38355061

发布时间 2024-03-11

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