Apium extract alleviates indomethacin-induced gastric ulcers in rats via modulating the VEGF and IK-κB/NF-κB p65 signaling pathway: insights from in silico and in vivo investigations.

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作者： Dalia H,Abu-Baih ^[1] ; Alshymaa Abdel-Rahman,Gomaa ^[2] ; Nada Mohamed,Abdel-Wahab ^[2] ; Enas Reda,Abdelaleem ^[2] ; Azza M Abdel,Zaher ^[3] ; Noha F,Hassan ^[4] ; Gerhard,Bringmann ^[5] ; Usama Ramadan,Abdelmohsen ^[6] ; Faisal H,Altemani ^[7] ; Naseh A,Algehainy ^[8] ; Fatma Alzahraa,Mokhtar ^[8] ; Miada F,Abdelwahab ^[9]

作者单位： Department of Biochemistry, Faculty of Pharmacy, Deraya University, New Minia, 61111, Egypt. ^[1] Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt. ^[2] Department of Pathology, Faculty of Medicine, Minia University, Minia, Egypt. ^[3] Department of Pharmacology and Toxicology, Faculty of Pharmacy, Modern University for Technology and Information, Cairo, 11571, Egypt. ^[4] Institute of Organic Chemistry, University of Würzburg, Am Hubland, Würzburg, 97074, Germany. ^[5] Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt. usama.ramadan@mu.edu.eg. ^[6] Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, Minia, 61111, Egypt. usama.ramadan@mu.edu.eg. ^[7] Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, 71491, Saudi Arabia. ^[8] Fujairah Research Centre, Sakamkam Road, Fujairah, United Arab Emirates. ^[9] Department of pharmacognosy, Faculty of pharmacy, El Saleheya El Gadida University, El Saleheya El Gadida, 44813, Sharkia, Egypt. ^[10]

关键词 Apium graveolens L.Gastric ulcer Inflammatory cytokines Metabolomic profiling Network pharmacology

主题词大鼠(Rats);动物(Animals);胃溃疡(Stomach Ulcer);吲哚美辛(Indomethacin);血管内皮生长因子A(Vascular Endothelial Growth Factor A);NF-κB(NF-kappa B);抗溃疡病药(Anti-Ulcer Agents);植物提取物(Plant Extracts);信号传导(Signal Transduction)

DOI 10.1186/s12906-023-04333-w

PMID 38355510

发布时间 2024-02-17

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BMC complementary medicine and therapies

2024年24卷1期

88页

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Apium extract alleviates indomethacin-induced gastric ulcers in rats via modulating the VEGF and IK-κB/NF-κB p65 signaling pathway: insights from in silico and in vivo investigations.

BMC complementary medicine and therapies

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BMC complementary medicine and therapies

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Apium extract alleviates indomethacin-induced gastric ulcers in rats via modulating the VEGF and IK-κB/NF-κB p65 signaling pathway: insights from in silico and in vivo investigations.

BMC complementary medicine and therapies

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BMC complementary medicine and therapies

相关期刊

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