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Rapid and high-purity differentiation of human medium spiny neurons reveals LMNB1 hypofunction and subtype necessity in modeling Huntington's disease.

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第一作者： Junjiao,Wu

第一单位： Department of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha, 410008, China.;Provincial Clinical Research Center for Rheumatic and Immunologic Diseases, Xiangya Hospital, Central South University, Changsha, 410008, China.

作者： Junjiao,Wu ^[1] ; Jie,Ren ^[2] ; Hongfei,Cui ^[2] ; Yali,Xie ^[2] ; Yu,Tang ^[3]

作者单位： Department of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha, 410008, China.;Provincial Clinical Research Center for Rheumatic and Immunologic Diseases, Xiangya Hospital, Central South University, Changsha, 410008, China. ^[1] Department of Geriatrics, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. ^[2] Department of Geriatrics, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. tangyusky@csu.edu.cn.;Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China. tangyusky@csu.edu.cn.;Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, 410008, China. tangyusky@csu.edu.cn. ^[3]

关键词 Human pluripotent stem cells Huntington’s disease LMNB1 Medium spiny neuron Nucleocytoplasmic transport

DOI 10.1186/s41232-024-00320-x

PMID 38360694

发布时间 2024-02-18

基金项目

82271280/National Natural Sciences Foundation of China 82301433/National Natural Sciences Foundation of China

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准确一般字义偏差语意偏离译文作用小提交