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Discovery and optimization of dihydropteridone derivatives as novel PLK1 and BRD4 dual inhibitor for the treatment of cancer.

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第一作者： Jiuyu,Liu

第一单位： School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, Liaoning 110016, China.

作者： Jiuyu,Liu ^[1] ; Jingxuan,Huang ^[1] ; Kang,Wang ^[1] ; Yuan,Li ^[1] ; Chunting,Li ^[1] ; Yanli,Zhu ^[1] ; Xinzi,He ^[1] ; Yating,Zhang ^[1] ; Yanfang,Zhao ^[1] ; Changliang,Hu ^[2] ; Zhiguo,Xi ^[2] ; Minghui,Tong ^[2] ; Zhiwei,Li ^[3] ; Ping,Gong ^[4] ; Yunlei,Hou ^[5]

作者单位： School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, Liaoning 110016, China. ^[1] 3D BioOptima, 1338 Wuzhong Avenue, Suzhou 215104, China. ^[2] School of Medicine and Health, Yancheng Polytechnic College, 285 Jiefang South Road, Yancheng, Jiangsu 224005, China. ^[3] School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, Liaoning 110016, China. Electronic address: gongpinggp@126.com. ^[4] School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, Liaoning 110016, China. Electronic address: houyunlei901202@163.com. ^[5]

关键词 Anticancer activity Dihydropteridone derivatives Isoindolin-1-one or isoindoline moieties PLK1/BRD4 dual inhibitors Structure activity relationship