Progranulin promotes regulatory T cells plasticity by mitochondrial metabolism through AMPK/PGC-1α pathway in ARDS.

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第一作者： Yanqing,Chen

第一单位： Department of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; The Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

作者： Yanqing,Chen ^[1] ; Minkang,Guo ^[2] ; Ke,Xie ^[3] ; Ming,Lei ^[4] ; Yusen,Chai ^[5] ; Zhengtao,Zhang ^[3] ; Zhenhua,Deng ^[3] ; Qiaozhi,Peng ^[3] ; Ju,Cao ^[6] ; Shihui,Lin ^[7] ; Fang,Xu ^[8]

作者单位： Department of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; The Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. ^[1] Department of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; The Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. ^[2] Department of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. ^[3] Department of Critical Care Medicine, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China. ^[4] Department of Anaesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, University Hospital Carl Gustav Carus Dresden at Technische Universität Dresden, Dresden, Germany. ^[5] Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. ^[6] Department of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address: linshihui07@126.com. ^[7] Department of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address: xufang828@126.com. ^[8]

关键词 Acute respiratory distress syndrome (ARDS)Immunosenescence Metabolic reprogramming Mitochondria Progranulin (PGRN)Regulatory T cells (Tregs)