Targeting 14-3-3θ-mediated TDP-43 pathology in amyotrophic lateral sclerosis and frontotemporal dementia mice.

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第一作者： Yazi D,Ke

第一单位： Dementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia. Electronic address: yazi.ke@mq.edu.au.

作者： Yazi D,Ke ^[1] ; Annika,van Hummel ^[2] ; Carol,Au ^[2] ; Gabriella,Chan ^[2] ; Wei Siang,Lee ^[2] ; Julia,van der Hoven ^[2] ; Magdalena,Przybyla ^[2] ; Yuanyuan,Deng ^[2] ; Miheer,Sabale ^[2] ; Nicolle,Morey ^[2] ; Josefine,Bertz ^[2] ; Astrid,Feiten ^[2] ; Stefania,Ippati ^[2] ; Claire H,Stevens ^[3] ; Shu,Yang ^[4] ; Amadeus,Gladbach ^[2] ; Nikolas K,Haass ^[5] ; Jillian J,Kril ^[6] ; Ian P,Blair ^[4] ; Fabien,Delerue ^[2] ; Lars M,Ittner ^[7]

作者单位： Dementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia. Electronic address: yazi.ke@mq.edu.au. ^[1] Dementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia. ^[2] School of Chemistry and Molecular Bioscience, University of Wollongong and Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia. ^[3] Centre for MND Research, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia. ^[4] The University of Queensland Diamantina Institute, Translational Research Institute, The University of Queensland, Brisbane, QLD 4102, Australia. ^[5] Dementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia; School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2050, Australia. ^[6] Dementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia. Electronic address: lars.ittner@mq.edu.au. ^[7]

关键词 14-3-3 TDP-43 amyotrophic lateral sclerosis frontotemporal dementia gene therapy mouse model

主题词动物(Animals);小鼠(Mice);肌萎缩侧索硬化(Amyotrophic Lateral Sclerosis);DNA结合蛋白质类(DNA-Binding Proteins);额颞叶痴呆(Frontotemporal Dementia);神经元(Neurons)

DOI 10.1016/j.neuron.2024.01.022

PMID 38366598

发布时间 2024-04-25

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