A mutation in LPAR2 activates the miR-939-5p-LPAR2-PI3K/AKT axis to regulate the proliferation and apoptosis of granulosa cells in sheep.

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作者： Runan,Zhang ^[1] ; Yufang,Liu ^[2] ; Wentao,Li ^[2] ; Peng,Wang ^[2] ; Ziyi,Liu ^[2] ; Yuliang,Wen ^[3] ; Mingxing,Chu ^[4] ; Linjie,Wang ^[5]

作者单位： Key Laboratory of Livestock and Poultry Multiomics, Ministry of Agriculture and Rural Affairs, College of Animal and Technology, Sichuan Agricultural University, Chengdu 611130, China; State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China. ^[1] State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China. ^[2] College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang 453003, China. ^[3] State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China. Electronic address: mxchu@263.net. ^[4] Key Laboratory of Livestock and Poultry Multiomics, Ministry of Agriculture and Rural Affairs, College of Animal and Technology, Sichuan Agricultural University, Chengdu 611130, China. Electronic address: wanglinjie@sicau.edu.cn. ^[5]

关键词 Granulosa cell proliferation LPAR2 Litter size Sheep Single-nucleotide polymorphism (SNP)