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Evaluation of single-use optical and electrochemical pH sensors in upstream bioprocessing.

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第一作者： Erica J,Fratz-Berilla

第一单位： U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Quality, Office of Biotechnology Products, Division of Biotechnology Review and Research II, Silver Spring, MD, USA.

作者： Erica J,Fratz-Berilla ^[1] ; Casey,Kohnhorst ^[1] ; Nicholas,Trunfio ^[1] ; Xin,Bush ^[2] ; Aron,Gyorgypal ^[3] ; Cyrus,Agarabi ^[1]

作者单位： U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Quality, Office of Biotechnology Products, Division of Biotechnology Review and Research II, Silver Spring, MD, USA. ^[1] U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Quality, Office of Biotechnology Products, Division of Biotechnology Review and Research II, Silver Spring, MD, USA.;Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI, USA. ^[2] Department of Chemical and Biochemical Engineering, School of Engineering, Rutgers the State University of New Jersey, Piscataway, NJ, 08854, USA. ^[3]

关键词 Biomanufacturing Bioprocessing Bioreactors CHO Chinese hamster ovary cells Monoclonal antibodies Process control Single-use technology pH control pH sensor

DOI 10.1016/j.heliyon.2024.e25512

PMID 38371965

发布时间 2024-02-20

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Evaluation of single-use optical and electrochemical pH sensors in upstream bioprocessing.

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Evaluation of single-use optical and electrochemical pH sensors in upstream bioprocessing.

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