Systemic immune response to a CD40 agonist antibody in nonhuman primates.

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作者： David L,Caudell ^[1] ; Gregory O,Dugan ^[1] ; Galina,Babitzki ^[2] ; Christine,Schubert ^[3] ; Annamaria,Braendli-Baiocco ^[3] ; Ken,Wasserman ^[4] ; Gonzalo,Acona ^[5] ; Martin,Stern ^[6] ; Alexandre,Passioukov ^[5] ; J Mark,Cline ^[1] ; Jehad,Charo ^[5]

作者单位： Section on Comparative Medicine, Department of Pathology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, United States. ^[1] Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Diagnostics GmbH, F. Hoffmann-La Roche AG, Staffelseestrasse 2-8, 81477 Munich, Germany. ^[2] Pharmaceutical Research and Early Development, Pharmaceutical Science, Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Grenzacherstrasse 124, 4070 Basel, Switzerland. ^[3] Department of Biochemistry and Molecular and Cellular Biology, Georgetown University School of Medicine, 3900 Reservoir Rd NW #337, Washington, DC 20007, United States. ^[4] Pharmaceutical Research and Early Development Oncology, Roche Innovation Center Zurich, F. Hoffmann-La Roche AG, Wagistrasse 10, 8952 Schlieren, Zurich, Switzerland. ^[5] Pharmaceutical Research and Early Development Oncology, Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Grenzacherstrasse 124, 4070 Basel, Switzerland. ^[6]

关键词 B cells CD40 T cells dendritic cells immunotherapy lymph node nonhuman primate spleen

主题词动物(Animals);抗体, 单克隆(Antibodies, Monoclonal);成束猴(Macaca fascicularis);肿瘤(Neoplasms)

DOI 10.1093/jleuko/qiae031

PMID 38372596

发布时间 2024-12-10

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