Substrate promiscuity of inositol 1,4,5-trisphosphate kinase driven by structurally-modified ligands and active site plasticity.

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作者： María Ángeles,Márquez-Moñino ^[1] ; Raquel,Ortega-García ^[1] ; Hayley,Whitfield ^[2] ; Andrew M,Riley ^[3] ; Lourdes,Infantes ^[1] ; Shane W,Garrett ^[4] ; Megan L,Shipton ^[3] ; Charles A,Brearley ^[2] ; Barry V L,Potter ^[5] ; Beatriz,González ^[6]

作者单位： Department of Crystallography and Structural Biology, Institute of Physical-Chemistry Blas Cabrera, CSIC, Serrano 119, 28006, Madrid, Spain. ^[1] School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK. ^[2] Drug Discovery and Medicinal Chemistry, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK. ^[3] Wolfson Laboratory of Medicinal Chemistry, Department of Life Sciences, University of Bath, Claverton Down, Bath, BA2 7AY, UK. ^[4] Drug Discovery and Medicinal Chemistry, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK. barry.potter@pharm.ox.ac.uk. ^[5] Wolfson Laboratory of Medicinal Chemistry, Department of Life Sciences, University of Bath, Claverton Down, Bath, BA2 7AY, UK. barry.potter@pharm.ox.ac.uk. ^[6] Department of Crystallography and Structural Biology, Institute of Physical-Chemistry Blas Cabrera, CSIC, Serrano 119, 28006, Madrid, Spain. xbeatriz@iqf.csic.es. ^[7]