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Intra-prostatic tumour evolution, steps in metastatic spread and histogenomic associations revealed by integration of multi-region whole-genome sequencing with histopathological features.

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第一作者： Srinivasa,Rao

第一单位： Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK. Srinivasa.rao@nds.ox.ac.uk.;Botnar Research Centre, Windmill Road, Oxford, OX3 7LD, UK. Srinivasa.rao@nds.ox.ac.uk.

作者： Srinivasa,Rao ^[1] ; Clare,Verrill ^[2] ; Lucia,Cerundolo ^[2] ; Nasullah Khalid,Alham ^[2] ; Zeynep,Kaya ^[3] ; Miriam,O'Hanlon ^[2] ; Alicia,Hayes ^[2] ; Adam,Lambert ^[2] ; Martha,James ^[2] ; Iain D C,Tullis ^[4] ; Jane,Niederer ^[2] ; Shelagh,Lovell ^[2] ; Altan,Omer ^[2] ; Francisco,Lopez ^[2] ; Tom,Leslie ^[2] ; Francesca,Buffa ^[4] ; Richard J,Bryant ^[2] ; Alastair D,Lamb ^[2] ; Boris,Vojnovic ^[4] ; David C,Wedge ^[5] ; Ian G,Mills ^[2] ; Dan J,Woodcock ^[2] ; Ian,Tomlinson ^[4] ; Freddie C,Hamdy ^[2]

作者单位： Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK. Srinivasa.rao@nds.ox.ac.uk.;Botnar Research Centre, Windmill Road, Oxford, OX3 7LD, UK. Srinivasa.rao@nds.ox.ac.uk. ^[1] Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK. ^[2] Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. ^[3] Department of Oncology, University of Oxford, Oxford, UK. ^[4] Manchester Cancer Research Centre, University of Manchester, Manchester, UK. ^[5]

关键词 Cancer evolution Histopathology Intra-tumour heterogeneity Prostate cancer Prostate cancer metastasis Spatial genomic analysis

医学主题词男(雄)性(Male);人类(Humans);种系发生(Phylogeny);前列腺肿瘤(Prostatic Neoplasms);前列腺(Prostate);淋巴转移(Lymphatic Metastasis);精囊(Seminal Vesicles)

DOI 10.1186/s13073-024-01302-x

PMID 38374116

发布时间 2026-02-04

基金项目

25812/CRUK_/Cancer Research UK/United Kingdom 18444/CRUK_/Cancer Research UK/United Kingdom C1994/A28701/CRUK_/Cancer Research UK/United Kingdom C1380/A18444/CRUK_/Cancer Research UK/United Kingdom 28701/CRUK_/Cancer Research UK/United Kingdom

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