Generation of allogenic chimera carrying mutations in PDX1 and TP53 genes via phytohemagglutinin-mediated blastomere aggregation in pigs.

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作者： Thanh-Van,Nguyen ^[1] ; Koki,Takebayashi ^[2] ; Lanh Thi Kim,Do ^[1] ; Zhao,Namula ^[3] ; Manita,Wittayarat ^[4] ; Megumi,Nagahara ^[2] ; Maki,Hirata ^[2] ; Takeshige,Otoi ^[2] ; Fuminori,Tanihara ^[5]

作者单位： Faculty of Bioscience and Bioindustry, Tokushima University, Ishii, Myozai-Gun, Tokushima, 7793233, Japan.;Faculty of Veterinary Medicine, Vietnam National University of Agriculture, Hanoi, 100000, Vietnam. ^[1] Faculty of Bioscience and Bioindustry, Tokushima University, Ishii, Myozai-Gun, Tokushima, 7793233, Japan.;Bio-Innovation Research Center, Tokushima University, Ishii, Myozai-Gun, Tokushima, 7793233, Japan. ^[2] Faculty of Bioscience and Bioindustry, Tokushima University, Ishii, Myozai-Gun, Tokushima, 7793233, Japan.;College of Coastal Agricultural Sciences, Guangdong Ocean University, Zhanjiang, 524088, China. ^[3] Faculty of Veterinary Science, Prince of Songkla University, Songkhla, 90110, Thailand. ^[4] Faculty of Bioscience and Bioindustry, Tokushima University, Ishii, Myozai-Gun, Tokushima, 7793233, Japan. f_tanihara@jichi.ac.jp.;Center for Development of Advanced Medical Technology, Jichi Medical University, Shimotsuke, Tochigi, 3290498, Japan. f_tanihara@jichi.ac.jp. ^[5]

关键词 Allogenic chimera CRISPR/Cas9 Pancreatic cancer Pancreatic tumor model