Targeting Senescent Alveolar Epithelial Cells Using Engineered Mesenchymal Stem Cell-Derived Extracellular Vesicles To Treat Pulmonary Fibrosis.

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第一作者： Yaoying,Long

第一单位： Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

作者： Yaoying,Long ^[1] ; Bianlei,Yang ^[2] ; Qian,Lei ^[3] ; Fei,Gao ^[4] ; Li,Chen ^[4] ; Wenlan,Chen ^[1] ; Siyi,Chen ^[2] ; Wenxiang,Ren ^[1] ; Yulin,Cao ^[2] ; Liuyue,Xu ^[1] ; Di,Wu ^[1] ; Jiao,Qu ^[1] ; He,Li ^[1] ; Yali,Yu ^[2] ; Anyuan,Zhang ^[1] ; Shan,Wang ^[1] ; Weiqun,Chen ^[5] ; Hongxiang,Wang ^[4] ; Ting,Chen ^[6] ; Zhichao,Chen ^[1] ; Qiubai,Li ^[2]

作者单位： Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. ^[1] Department of Rheumatology and Immunology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. ^[2] West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu 610041, China. ^[3] Department of Hematology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China. ^[4] Key Laboratory for Molecular Diagnosis of Hubei Province, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China. ^[5] Hubei Engineering Research Center for Application of Extracellular Vesicle, Hubei University of Science and Technology, Xianning 437100, China. ^[6]

关键词 CD38 alveolar epithelial cells extracellular vesicles mesenchymal stem cells pulmonary fibrosis senescence

主题词人类(Humans);小鼠(Mice);动物(Animals);肺纤维化(Pulmonary Fibrosis);NAD(NAD);间质干细胞(Mesenchymal Stem Cells);受体, 抗原(Receptors, Antigen)

DOI 10.1021/acsnano.3c10547

PMID 38381372

发布时间 2024-03-09

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