首页> Journal of medicinal chemistry> Structure Guided Discovery of Novel Pan Metallo-β-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration.

Structure Guided Discovery of Novel Pan Metallo-β-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration.

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第一作者： Shuzhi,Dong

第一单位： Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States.

作者： Shuzhi,Dong ^[1] ; Zhiqiang,Zhao ^[1] ; Haiqun,Tang ^[1] ; Guoqing,Li ^[1] ; Jianping,Pan ^[1] ; Xin,Gu ^[1] ; Jinlong,Jiang ^[1] ; Li,Xiao ^[2] ; Giovanna,Scapin ^[2] ; David N,Hunter ^[1] ; Dexi,Yang ^[1] ; Yuhua,Huang ^[1] ; Frank,Bennett ^[1] ; Shu-Wei,Yang ^[1] ; Mihirbaran,Mandal ^[1] ; Haifeng,Tang ^[1] ; Jing,Su ^[1] ; Clare,Tudge ^[1] ; Reynalda Keh,deJesus ^[1] ; Fa-Xiang,Ding ^[1] ; Matthew,Lombardo ^[1] ; Jacqueline D,Hicks ^[1] ; Thierry,Fischmann ^[2] ; Asra,Mirza ^[3] ; Priya,Dayananth ^[4] ; Ronald E,Painter ^[4] ; Artjohn,Villafania ^[4] ; Charles G,Garlisi ^[4] ; Rumin,Zhang ^[4] ; Todd W,Mayhood ^[4] ; Qian,Si ^[4] ; Nianyu,Li ^[5] ; Rupesh P,Amin ^[5] ; Bhavana,Bhatt ^[5] ; Feifei,Chen ^[5] ; Christopher P,Regan ^[5] ; Hillary,Regan ^[5] ; Xinjie,Lin ^[6] ; Jin,Wu ^[6] ; Andrew,Leithead ^[7] ; Scott R,Pollack ^[8] ; Jack D,Scott ^[1] ; Ravi P,Nargund ^[1] ; Alex G,Therien ^[9] ; Todd,Black ^[3] ; Katherine,Young ^[3] ; Alexander,Pasternak ^[1]

作者单位： Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States. ^[1] Computational and Structural Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States. ^[2] Antibacterial/Antifungal, Merck & Co., Inc., West Point, Pennsylvania 19486, United States. ^[3] Quantitative Biosciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States. ^[4] Nonclinical Drug Safety, Merck & Co., Inc., West Point, Pennsylvania 19486, United States. ^[5] Pharmacokinetics Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., Rahway, New Jersey 07065, United States. ^[6] Discovery Pharmaceutical Sciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States. ^[7] Discovery Process Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States. ^[8] Exploratory Science Center, Merck & Co., Inc., Cambridge, Massachusetts 02139, United States. ^[9]

医学主题词人类(Humans);抗菌药(Anti-Bacterial Agents);亚胺培南(Imipenem);β-内酰胺酶类(beta-Lactamases);革兰氏阴性菌(Gram-Negative Bacteria);微生物敏感性试验(Microbial Sensitivity Tests)

DOI 10.1021/acs.jmedchem.3c01614

PMID 38387069

发布时间 2025-01-27

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