Structural Basis for Multivalent MUC16 Recognition and Robust Anti-Pancreatic Cancer Activity of Humanized Antibody AR9.6.

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第一作者： Eric N,Aguilar

第一单位： Department of Chemistry and Biochemistry, California State University Fresno, Fresno, California.

作者： Eric N,Aguilar ^[1] ; Satish,Sagar ^[2] ; Brandy R,Murray ^[1] ; Christabelle,Rajesh ^[2] ; Eric K,Lei ^[3] ; Sarah A,Michaud ^[4] ; David R,Goodlett ^[4] ; Thomas C,Caffrey ^[2] ; Paul M,Grandgenett ^[2] ; Benjamin,Swanson ^[5] ; Teresa M,Brooks ^[1] ; Adrian R,Black ^[2] ; Henk,van Faassen ^[3] ; Greg,Hussack ^[3] ; Kevin A,Henry ^[6] ; Michael A,Hollingsworth ^[2] ; Cory L,Brooks ^[1] ; Prakash,Radhakrishnan ^[2]

作者单位： Department of Chemistry and Biochemistry, California State University Fresno, Fresno, California. ^[1] Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska.;Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska. ^[2] Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, Canada. ^[3] University of Victoria-Genome BC Proteomics Centre, Victoria, British Columbia, Canada. ^[4] Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska. ^[5] Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, Canada.;Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada. ^[6]