Ruxolitinib Pharmacokinetics and Pharmacodynamics in Children with Acute and Chronic Graft-versus-Host Disease.

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第一作者： Eleanor,Cook

第一单位： Division of Bone Marrow Transplant and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.

作者： Eleanor,Cook ^[1] ; Min,Dong ^[2] ; Samuel C C,Chiang ^[1] ; David,Luedeke ^[3] ; Kelly E,Lake ^[1] ; Colin,Hoerth ^[1] ; Marisa,Deavy ^[1] ; Kenneth D R,Setchell ^[4] ; Junfang,Zhao ^[5] ; Nieko,Punt ^[6] ; Thomas,Galletta ^[7] ; Ashley,Teusink-Cross ^[1] ; Stella M,Davies ^[1] ; Rebecca A,Marsh ^[1] ; Parinda,Mehta ^[1] ; Pooja,Khandelwal ^[8]

作者单位： Division of Bone Marrow Transplant and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio. ^[1] Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio; Division of Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. ^[2] Division of Bone Marrow Transplant and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. ^[3] Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio; Division of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States. ^[4] Division of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States. ^[5] Medimatics, Maastricht, The Netherlands; Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. ^[6] Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio; Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. ^[7] Division of Bone Marrow Transplant and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio. Electronic address: Pooja.khandelwal@cchmc.org. ^[8]

关键词 Pediatric ruxolitinib Ruxolitinib Ruxolitinib for GVHD

主题词青少年(Adolescent);儿童(Child);儿童, 学龄前(Child, Preschool);女(雌)性(Female);人类(Humans);婴儿(Infant);男(雄)性(Male);急性病(Acute Disease);慢性病(Chronic Disease);移植物抗宿主病(Graft vs Host Disease);造血干细胞移植(Hematopoietic Stem Cell Transplantation);腈类(Nitriles);前瞻性研究(Prospective Studies);吡唑类(Pyrazoles);嘧啶类(Pyrimidines);STAT1转录因子(STAT1 Transcription Factor);STAT3转录因子(STAT3 Transcription Factor);STAT5转录因子(STAT5 Transcription Factor)

DOI 10.1016/j.jtct.2024.02.018

PMID 38401793

发布时间 2024-07-31

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Transplantation and cellular therapy

2024年30卷5期

528.e1-528.e12页

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Ruxolitinib Pharmacokinetics and Pharmacodynamics in Children with Acute and Chronic Graft-versus-Host Disease.

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Ruxolitinib Pharmacokinetics and Pharmacodynamics in Children with Acute and Chronic Graft-versus-Host Disease.

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