Modulation of the crosstalk between Keap1/Nrf2/HO-1 and NF-κB signaling pathways by Tomatidine protects against inflammation/oxidative stress-driven fulminant hepatic failure in mice.

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第一作者： Wesam H,Abdulaal

第一单位： Department of Biochemistry, Faculty of Science, Cancer and Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Center of Excellence for Drug Research and Pharmaceutical Industries, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Electronic address: whabdulaal@kau.edu.sa.

作者： Wesam H,Abdulaal ^[1] ; Ulfat M,Omar ^[2] ; Mustafa,Zeyadi ^[3] ; Dina S,El-Agamy ^[4] ; Nabil A,Alhakamy ^[5] ; Sabrin R M,Ibrahim ^[6] ; Naif A R,Almalki ^[7] ; Hani Z,Asfour ^[8] ; Mohammed W,Al-Rabia ^[9] ; Gamal A,Mohamed ^[10] ; Mahmoud,Elshal ^[11]

作者单位： Department of Biochemistry, Faculty of Science, Cancer and Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Center of Excellence for Drug Research and Pharmaceutical Industries, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Electronic address: whabdulaal@kau.edu.sa. ^[1] Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah, Saudi Arabia; Princess Dr. Najla Bint Saud Al-Saud Center for Excellence Research in Biotechnology, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address: uomer@kau.edu.sa. ^[2] Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address: mzyadi@kau.edu.sa. ^[3] Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. Electronic address: dinaagamy@mans.edu.eg. ^[4] Center of Excellence for Drug Research and Pharmaceutical Industries, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Mohamed Saeed Tamer Chair for Pharmaceutical Industries, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Electronic address: nalhakamy@kau.edu.sa. ^[5] Preparatory Year Program, Department of Chemistry, Batterjee Medical College, Jeddah 21442, Saudi Arabia; Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt. Electronic address: sabrin.ibrahim@bmc.edu.sa. ^[6] Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah, Saudi Arabia; Experimental Biochemistry unit, King Fahad Medical Research Centre, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address: naralmalki@kau.edu.sa. ^[7] Department of Clinical Microbiology and Immunology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address: hasfour@kau.edu.sa. ^[8] Department of Clinical Microbiology and Immunology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address: mwalrabia@kau.edu.sa. ^[9] Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Electronic address: gahussein@kau.edu.sa. ^[10] Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. Electronic address: mahmoudelshal@mans.edu.eg. ^[11]

关键词 Antioxidant and anti-inflammatory Fulminant hepatic failure Health and well-being Industrial development Steroidal alkaloid Tomatidine