Engineering Anti-CRISPR Proteins to Create CRISPR-Cas Protein Switches for Activatable Genome Editing and Viral Protease Detection.

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第一作者： Wenyuan,Kang

第一单位： State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, Hunan University, Changsha, 410082, P. R. China.;Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education & Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, 571158, P. R. China.

作者： Wenyuan,Kang ^[1] ; Fei,Xiao ^[2] ; Xi,Zhu ^[3] ; Xinyu,Ling ^[4] ; Shiyi,Xie ^[2] ; Ruimiao,Li ^[2] ; Peihang,Yu ^[2] ; Linxin,Cao ^[2] ; Chunyang,Lei ^[2] ; Ye,Qiu ^[3] ; Tao,Liu ^[4] ; Zhou,Nie ^[2]

作者单位： State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, Hunan University, Changsha, 410082, P. R. China.;Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education & Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, 571158, P. R. China. ^[1] State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, Hunan University, Changsha, 410082, P. R. China. ^[2] Hunan Provincial Key Laboratory of Medical Virology, Institute of Pathogen Biology and Immunology, College of Biology, Hunan University, Changsha, 410082, P. R. China. ^[3] State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Haidian District, Beijing, 100191, P. R. China. ^[4]

关键词 Anti-CRISPR Protein CRISPR-Cas Protein Engineering Protein Switch Viral Protease Detection

主题词动物(Animals);肽水解酶类(Peptide Hydrolases);内肽酶类(Endopeptidases);哺乳动物(Mammals)

DOI 10.1002/anie.202400599

PMID 38407550

发布时间 2024-07-30

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