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Metabolic heterogeneity in clear cell renal cell carcinoma revealed by single-cell RNA sequencing and spatial transcriptomics.

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第一作者： Guanwen,Yang

第一单位： Department of Urology, Zhongshan Hospital, Fudan University, 180Th Fengling Rd, Xuhui District, Shanghai, 200032, China.

作者： Guanwen,Yang ^[1] ; Jiangting,Cheng ^[1] ; Jiayi,Xu ^[1] ; Chenyang,Shen ^[1] ; Xuwei,Lu ^[2] ; Chang,He ^[2] ; Jiaqi,Huang ^[2] ; Minke,He ^[2] ; Jie,Cheng ^[3] ; Hang,Wang ^[4]

作者单位： Department of Urology, Zhongshan Hospital, Fudan University, 180Th Fengling Rd, Xuhui District, Shanghai, 200032, China. ^[1] Department of Urology, Minhang Hospital, Fudan University, Shanghai, 201199, China. ^[2] Department of Urology, Xuhui Hospital, Fudan University, 966Th Huaihai Middle Rd, Xuhui District, Shanghai, 200031, China. 13818908753@163.com. ^[3] Department of Urology, Zhongshan Hospital, Fudan University, 180Th Fengling Rd, Xuhui District, Shanghai, 200032, China. wang.hang@zs-hospital.sh.cn. ^[4]

关键词 Clear cell renal cell carcinoma Deep learning Metabolic reprogramming Single-cell RNA sequencing Spatial transcriptome Tumor microenvironment

医学主题词人类(Humans);癌, 肾细胞(Carcinoma, Renal Cell);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);基因表达谱(Gene Expression Profiling);脂类代谢(Lipid Metabolism);肾肿瘤(Kidney Neoplasms);肿瘤微环境(Tumor Microenvironment)

DOI 10.1186/s12967-024-04848-x

PMID 38414015

发布时间 2024-07-11

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