Sequential administration of delta-tocotrienol ameliorates radiation-induced myelosuppression in mice and non-human primates through inducing G-CSF production.

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第一作者： Shaozheng,Wang

第一单位： Beijing Key Laboratory for Radiobiology, Department of Experimental Hematology and Biochemistry, Beijing Institute of Radiation Medicine, No.27 Taiping Road, Haidian District, 100850, Beijing, China.

作者： Shaozheng,Wang ^[1] ; Zongchao,Zuo ^[2] ; Zhangyi,Ouyang ^[1] ; Xinyu,Liu ^[3] ; Junke,Wang ^[1] ; Yajun,Shan ^[1] ; Ruoxi,Meng ^[1] ; Zhenhu,Zhao ^[1] ; Xiaolan,Liu ^[1] ; Xiaoyan,Liu ^[1] ; Yiguang,Jin ^[1] ; Zhongtang,Li ^[4] ; Hong,Zhang ^[5] ; Limei,Wang ^[6] ; Yuwen,Cong ^[7]

作者单位： Beijing Key Laboratory for Radiobiology, Department of Experimental Hematology and Biochemistry, Beijing Institute of Radiation Medicine, No.27 Taiping Road, Haidian District, 100850, Beijing, China. ^[1] Beijing Key Laboratory for Radiobiology, Department of Experimental Hematology and Biochemistry, Beijing Institute of Radiation Medicine, No.27 Taiping Road, Haidian District, 100850, Beijing, China; Faculty of Environment and Life, Beijing University of Technology, No.100, Pingleyuan, Chaoyang, 100124, Beijing, China. ^[2] Beijing Key Laboratory for Radiobiology, Department of Experimental Hematology and Biochemistry, Beijing Institute of Radiation Medicine, No.27 Taiping Road, Haidian District, 100850, Beijing, China; College of Life Sciences, Hebei University, No.180 Wusi East Road, 071000, Baoding, China. ^[3] State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, No.38 Xueyuan Road, Haidian District, 100191, Beijing, China. ^[4] Beijing Key Laboratory for Radiobiology, Department of Experimental Hematology and Biochemistry, Beijing Institute of Radiation Medicine, No.27 Taiping Road, Haidian District, 100850, Beijing, China. Electronic address: 13601192278@163.com. ^[5] Beijing Key Laboratory for Radiobiology, Department of Experimental Hematology and Biochemistry, Beijing Institute of Radiation Medicine, No.27 Taiping Road, Haidian District, 100850, Beijing, China. Electronic address: 15910939958@163.com. ^[6] Beijing Key Laboratory for Radiobiology, Department of Experimental Hematology and Biochemistry, Beijing Institute of Radiation Medicine, No.27 Taiping Road, Haidian District, 100850, Beijing, China. Electronic address: congyw@nic.bmi.ac.cn. ^[7]

关键词 Delta-tocotrienol Granulocyte colony-stimulating factor Hematopoietic acute radiation syndrome Nonhuman primates Radiation Radiomitigator