NIR-II imaging-guided precise photodynamic therapy for augmenting tumor-starvation therapy by glucose metabolism reprogramming interference.

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作者： Xiawei,Wu ^[1] ; Yong,Fan ^[2] ; Kairuo,Wang ^[1] ; Yunqiu,Miao ^[1] ; Yongliang,Chang ^[1] ; Jiang,Ming ^[2] ; Xinyue,Wang ^[1] ; Shengwei,Lu ^[1] ; Ruichi,Liu ^[1] ; Fan,Zhang ^[2] ; Yang,Zhang ^[3] ; Huanlong,Qin ^[4] ; Jianlin,Shi ^[5]

作者单位： Nanomedicine and Intestinal Microecology Research Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China. ^[1] Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, State Key Laboratory of Molecular Engineering of Polymers and iChem, Fudan University, Shanghai 200433, China. ^[2] Nanomedicine and Intestinal Microecology Research Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China. Electronic address: zhangyang0202@tongji.edu.cn. ^[3] Nanomedicine and Intestinal Microecology Research Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China. Electronic address: hlongqin@126.com. ^[4] State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics Chinese Academy of Sciences, Shanghai 200050, China. ^[5]

关键词 Colorectal cancer Glycolytic inhibition Metabolic reprogramming NIR-II imaging Photodynamic therapy

主题词光化学疗法(Photochemotherapy);人类(Humans);动物(Animals);光敏感药(Photosensitizing Agents);脱植基叶绿素类(Chlorophyllides);卟啉类(Porphyrins);葡萄糖(Glucose);纳米粒子(Nanoparticles);脱氧葡萄糖(Deoxyglucose);小鼠(Mice);红外线(Infrared Rays);细胞系, 肿瘤(Cell Line, Tumor);肿瘤(Neoplasms);己糖激酶(Hexokinase);线粒体(Mitochondria);糖酵解(Glycolysis)

DOI 10.1016/j.scib.2024.02.008

PMID 38418300

发布时间 2024-07-29

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