Cryo-EM structure of cell-free synthesized human histamine 2 receptor/G<sub>s</sub> complex in nanodisc environment.

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作者： Zoe,Köck ^[1] ; Kilian,Schnelle ^[2] ; Margherita,Persechino ^[3] ; Simon,Umbach ^[4] ; Hannes,Schihada ^[1] ; Dovile,Januliene ^[4] ; Kristian,Parey ^[2] ; Steffen,Pockes ^[3] ; Peter,Kolb ^[2] ; Volker,Dötsch ^[3] ; Arne,Möller ^[5] ; Daniel,Hilger ^[4] ; Frank,Bernhard ^[1]

作者单位： Centre for Biomolecular Magnetic Resonance, Institute for Biophysical Chemistry, Goethe-University of Frankfurt/Main, Frankfurt, Germany. ^[1] Department of Biology/Chemistry, Structural Biology section, University of Osnabrück, Osnabrück, Germany. ^[2] Center of Cellular Nanoanalytic Osnabrück (CellNanOs), University of Osnabrück, Osnabrück, Germany. ^[3] Department of Pharmaceutical Chemistry, University of Marburg, Marburg, Germany. ^[4] Institute of Pharmacy, University of Regensburg, Regensburg, Germany. ^[5] Department of Biology/Chemistry, Structural Biology section, University of Osnabrück, Osnabrück, Germany. arne.moeller@uni-osnabrueck.de. ^[6] Center of Cellular Nanoanalytic Osnabrück (CellNanOs), University of Osnabrück, Osnabrück, Germany. arne.moeller@uni-osnabrueck.de. ^[7] Department of Pharmaceutical Chemistry, University of Marburg, Marburg, Germany. daniel.hilger@pharmazie.uni-marburg.de. ^[8] Centre for Biomolecular Magnetic Resonance, Institute for Biophysical Chemistry, Goethe-University of Frankfurt/Main, Frankfurt, Germany. fbern@bpc.uni-frankfurt.de. ^[9]

主题词人类(Humans);组胺(Histamine);冷冻电子显微镜检查(Cryoelectron Microscopy);HEK293细胞(HEK293 Cells);大肠杆菌(Escherichia coli);受体, 组胺H2(Receptors, Histamine H2)

DOI 10.1038/s41467-024-46096-z

PMID 38418462

发布时间 2024-03-02

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