Simultaneous determination of BGT-002 and its acyl glucuronide metabolite ZM326E-M2 in human plasma by liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study.

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作者： Xueran,Zhu ^[1] ; Shumin,Cui ^[2] ; Xinjing,Liu ^[2] ; Mei,Zhang ^[2] ; Zhifu,Xie ^[2] ; Wei,Li ^[3] ; Jingya,Li ^[2] ; Fajun,Nan ^[2] ; Yangming,Zhang ^[4] ; Yan,Zhan ^[5] ; Xiaoyan,Chen ^[6]

作者单位： School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, PR China. ^[1] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, PR China. ^[2] Burgeon Therapeutics Co., Ltd., Shanghai 201203, PR China. ^[3] Burgeon Therapeutics Co., Ltd., Shanghai 201203, PR China. Electronic address: ymzhang@burgeon-cn.com. ^[4] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, PR China. Electronic address: yzhan@simm.ac.cn. ^[5] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, PR China; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, PR China. Electronic address: xychen@simm.ac.cn. ^[6]

关键词 ATP-Citrate Lyase Acyl glucuronide metabolite BGT-002 LC-MS/MS Pharmacokinetics Pseudo-MRM

主题词人类(Humans);色谱法, 液相(Chromatography, Liquid);串联质谱法(Tandem Mass Spectrometry);葡糖醛酸甙类(Glucuronides);投药, 口服(Administration, Oral);乙腈类(Acetonitriles)

DOI 10.1016/j.jpba.2024.116056

PMID 38428245

发布时间 2024-04-08

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