Improvement of NASH and liver fibrosis through modulation of the gut-liver axis by a novel intestinal FXR agonist.

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第一作者： An-Na,Moon

第一单位： College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon 21983, South Korea; iLeadBMS Co., Ltd., 614 Dongtangiheung-ro, Hwaseong-si 18469, South Korea.

作者： An-Na,Moon ^[1] ; François,Briand ^[2] ; Natalia,Breyner ^[2] ; Dong-Keun,Song ^[3] ; Martin Rønn,Madsen ^[4] ; Hongbin,Kim ^[5] ; Keonwoo,Choi ^[5] ; Yoonsuk,Lee ^[6] ; Wan,Namkung ^[7]

作者单位： College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon 21983, South Korea; iLeadBMS Co., Ltd., 614 Dongtangiheung-ro, Hwaseong-si 18469, South Korea. ^[1] Physiogenex, 280 rue de l'Hers, ZAC de la Masquère, Escalquens 31750, France. ^[2] iLeadBMS Co., Ltd., 614 Dongtangiheung-ro, Hwaseong-si 18469, South Korea. ^[3] Gubra, Hørsholm Kongevej 11B, Hørsholm 2970, Denmark. ^[4] KINS, Korean Institute of Nonclinical Study, 172 Dolma-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 13505, South Korea. ^[5] iLeadBMS Co., Ltd., 614 Dongtangiheung-ro, Hwaseong-si 18469, South Korea. Electronic address: ivo.lee@ileadbms.com. ^[6] College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon 21983, South Korea. Electronic address: wnamkung@yonsei.ac.kr. ^[7]

关键词 Bile acid FXR Gut Microbiota NASH Pruritus

主题词小鼠(Mice);动物(Animals);受体, 胞质和核(Receptors, Cytoplasmic and Nuclear);肝(Liver);肝硬化(Liver Cirrhosis);胆汁酸类和盐类(Bile Acids and Salts)

DOI 10.1016/j.biopha.2024.116331

PMID 38428307

发布时间 2024-03-27

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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2024年173卷

116331页

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Improvement of NASH and liver fibrosis through modulation of the gut-liver axis by a novel intestinal FXR agonist.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

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Improvement of NASH and liver fibrosis through modulation of the gut-liver axis by a novel intestinal FXR agonist.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

相关期刊

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