Non-invasive methods of monitoring Fe<sub>3</sub>O<sub>4</sub> magnetic nanoparticle toxicity in human liver HepaRG cells using impedance biosensing and Coherent anti-Stokes Raman spectroscopic (CARS) microscopy.

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作者： Joel,Kuhn ^[1] ; Alison,McDonald ^[2] ; Cyril,Mongoin ^[2] ; Graham,Anderson ^[3] ; Guillemette,Lafeuillade ^[2] ; Stephen,Mitchell ^[4] ; Alistair P D,Elfick ^[2] ; Pierre O,Bagnaninchi ^[3] ; Humphrey H P,Yiu ^[5] ; Leonard J,Nelson ^[6]

作者单位： Institute of Chemical Sciences, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, Scotland EH14 4AS, UK. ^[1] Institute for Bioengineering, School of Engineering, The University of Edinburgh, King's Buildings, Edinburgh EH9 3DW. ^[2] Centre for Regenerative Medicine. Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh BioQuarter, 5 Little France Drive, Edinburgh EH16 4UU, UK. ^[3] School of Biological Sciences, The Daniel Rutherford Building, Max Born Crescent, Edinburgh EH9 3BF, UK. ^[4] Institute of Chemical Sciences, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, Scotland EH14 4AS, UK. Electronic address: h.h.yiu@hw.ac.uk. ^[5] Institute for Bioengineering, School of Engineering, The University of Edinburgh, King's Buildings, Edinburgh EH9 3DW. Electronic address: l.nelson@ed.ac.uk. ^[6]

关键词 Coherent anti-Stokes Raman spectroscopic (CARS) microscopy HepaRG cells Impedance biosensing Lipid dynamics Magnetite Nanotoxicity PEGylated MNPs