首页> Journal of medicinal chemistry> Discovery of TRPA1 Antagonist <b>GDC-6599</b>: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease.

Discovery of TRPA1 Antagonist <b>GDC-6599</b>: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease.

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第一作者： Jack A,Terrett

第一单位： Paraza Pharma, Incorporated, 2525 Avenue Marie-Curie, Montreal, Quebec H4S 2E1, Canada.

作者： Jack A,Terrett ^[1] ; Justin Q,Ly ^[1] ; Paula,Katavolos ^[2] ; Catrin,Hasselgren ^[2] ; Steven,Laing ^[1] ; Fiona,Zhong ^[1] ; Elisia,Villemure ^[1] ; Martin,Déry ^[1] ; Robin,Larouche-Gauthier ^[1] ; Huifen,Chen ^[1] ; Daniel G,Shore ^[3] ; Wyne P,Lee ^[3] ; Eric,Suto ; Kevin,Johnson ; Marjory,Brooks ; Alyssa,Stablein ; Francis,Beaumier ; Léa,Constantineau-Forget ; Chantal,Grand-Maître ; Luce,Lépissier ; Stéphane,Ciblat ; Claudio,Sturino ; Yong,Chen ; Baihua,Hu ; Justin,Elstrott ; Vineela,Gandham ; Victory,Joseph ; Helen,Booler ; Gary,Cain ; Carolina,Chou ; Aaron,Fullerton ; Michelle,Lepherd ; Shannon,Stainton ; Elizabeth,Torres ; Konnie,Urban ; Lanlan,Yu ; Yu,Zhong ; Linda,Bao ; Kang-Jye,Chou ; Jessica,Lin ; Wei,Zhang ; Hank,La ; Liling,Liu ; Teresa,Mulder ; Jun,Chen ; Tania,Chernov-Rogan ; Adam R,Johnson ; David H,Hackos ; Rebecca,Leahey ; Shannon D,Shields ; Alessia,Balestrini ; Lorena,Riol-Blanco ; Brian S,Safina ; Matthew,Volgraf ; Steven,Magnuson ; Satoko,Kakiuchi-Kiyota

作者单位： Paraza Pharma, Incorporated, 2525 Avenue Marie-Curie, Montreal, Quebec H4S 2E1, Canada. ^[1] Department of Population Medicine and Diagnostic Sciences, Cornell University College of Veterinary Medicine, Ithaca, New York 14853, United States. ^[2] Pharmaron-Beijing Company Limited, 6 Taihe Road BDA, Beijing 100176, PR China. ^[3]

医学主题词人类(Humans);瞬时受体电位通道(Transient Receptor Potential Channels);醛氧化酶(Aldehyde Oxidase);氧化还原酶类(Oxidoreductases);细胞支架蛋白质类(Cytoskeletal Proteins);呼吸道疾病(Respiratory Tract Diseases)

DOI 10.1021/acs.jmedchem.3c02121

PMID 38431835

发布时间 2025-01-22

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准确一般字义偏差语意偏离译文作用小提交