首页> Cell reports> Liver-derived plasminogen mediates muscle stem cell expansion during caloric restriction through the plasminogen receptor Plg-R<sub>KT</sub>.

Liver-derived plasminogen mediates muscle stem cell expansion during caloric restriction through the plasminogen receptor Plg-R<sub>KT</sub>.

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第一作者： Akshay,Bareja

第一单位： Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA.

作者： Akshay,Bareja ^[1] ; David E,Lee ^[1] ; Tricia,Ho ^[2] ; Greg,Waitt ^[2] ; Lauren H,McKay ^[3] ; Sarah A,Hannou ^[4] ; Melissa C,Orenduff ^[4] ; Kristen M,McGreevy ^[5] ; Alexandra,Binder ^[6] ; Calen P,Ryan ^[7] ; Erik J,Soderblom ^[2] ; Daniel W,Belsky ^[7] ; Luigi,Ferrucci ^[8] ; Jayanta Kumar,Das ^[8] ; Nirad,Banskota ^[9] ; Virginia B,Kraus ^[10] ; Janet L,Huebner ^[4] ; William E,Kraus ^[10] ; Kim M,Huffman ^[10] ; Gurpreet S,Baht ^[11] ; Steve,Horvath ^[12] ; Robert J,Parmer ^[13] ; Lindsey A,Miles ^[14] ; James P,White ^[15]

作者单位： Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA. ^[1] Proteomics and Metabolomics Core Facility, Duke University School of Medicine, Durham, NC, USA. ^[2] Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA; Division of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of Chapel Hill, Chapel Hill, NC, USA. ^[3] Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA. ^[4] Department of Biostatistics, UCLA Fielding School of Public Health, Los Angeles, CA 90095, USA. ^[5] Population Sciences in the Pacific Program (Cancer Epidemiology), University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, HI 96813, USA; Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA 90095, USA. ^[6] Columbia University Mailman School of Public Health, New York, NY, USA. ^[7] Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. ^[8] Longitudinal Studies Section, Translation Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA. ^[9] Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA; Duke Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, NC 27701, USA. ^[10] Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA; Duke Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, NC 27701, USA; Department of Orthopedic Surgery, Duke University School of Medicine, Durham, NC 27701, USA. ^[11] Computational Biology and Genomics Core, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA; Altos Labs, San Diego, CA, USA. ^[12] Department of Medicine, Veterans Administration San Diego Healthcare System, San Diego, CA, USA; Department of Medicine, University of California San Diego, La Jolla, CA, USA. ^[13] Department of Molecular Medicine, Scripps Research, La Jolla, CA 92037, USA. ^[14] Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA; Duke Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, NC 27701, USA. Electronic address: james.white@duke.edu. ^[15]

关键词 CALERIE CP: Metabolism CP: Stem cell research MetRS PAI-1 caloric restriction liver muscle plasminogen satellite cell secretome stem cell

医学主题词小鼠(Mice);动物(Animals);人类(Humans);纤维蛋白溶酶原(Plasminogen);受体, 细胞表面(Receptors, Cell Surface);热量限制(Caloric Restriction);肝(Liver);小鼠, 转基因(Mice, Transgenic);丝氨酸蛋白酶类(Serine Proteases);细胞增殖(Cell Proliferation);肌(Muscles)

DOI 10.1016/j.celrep.2024.113881

PMID 38442019

发布时间 2025-01-15

基金项目

R33 AG070455/AG/NIA NIH HHS/United States T32 HL007057/HL/NHLBI NIH HHS/United States R01 AG061378/AG/NIA NIH HHS/United States R21 AG067245/AG/NIA NIH HHS/United States K01 AG056664/AG/NIA NIH HHS/United States R01 HL081046/HL/NHLBI NIH HHS/United States I01 BX003933/BX/BLRD VA/United States R21 AG065943/AG/NIA NIH HHS/United States R01 AG081393/AG/NIA NIH HHS/United States R01 HL149511/HL/NHLBI NIH HHS/United States P30 AG028716/AG/NIA NIH HHS/United States

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