Hawthorn leaf flavonoids alleviate the deterioration of atherosclerosis by inhibiting SCAP-SREBP2-LDLR pathway through sPLA2-ⅡA signaling in macrophages in mice.

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作者： Xufeng,Bai ^[1] ; Shuwen,Wang ^[1] ; Limei,Shu ^[1] ; Qingyu,Cao ^[2] ; Huiming,Hu ^[3] ; Yanchen,Zhu ^[4] ; Chen,Chen ^[5]

作者单位： College of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang, 330004, China. ^[1] College of Pharmacy, Nanchang Medical College, Nanchang, Jiangxi, 330052, China. ^[2] College of Pharmacy, Nanchang Medical College, Nanchang, Jiangxi, 330052, China; Key Laboratory of Pharmacodynamics and Quality Evaluation on Anti-Inflammatory Chinese Herbs, Jiangxi Administration of Traditional Chinese Medicine, Jiangxi, 330052, China; School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, Queensland, 4072, Australia. Electronic address: huhuiming@ncmc.edu.cn. ^[3] College of Computer Science, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, 330004, China. Electronic address: 20030761@jxutcm.edu.cn. ^[4] School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, Queensland, 4072, Australia. Electronic address: chen.chen@uq.edu.au. ^[5]

关键词 Atherosclerosis Hawthorn leaf flavonoids Inflammation Macrophages SCAP-SREBP2-LDLR sPLA2-ⅡA