FM19G11-loaded nanoparticles modulate energetic status and production of reactive oxygen species in myoblasts from ALS mice.

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作者： Claudia,Malacarne ^[1] ; Eleonora,Giagnorio ^[2] ; Cristina,Chirizzi ^[3] ; Marco,Cattaneo ^[4] ; Fulvia,Saraceno ^[5] ; Paola,Cavalcante ^[1] ; Silvia,Bonanno ^[1] ; Renato,Mantegazza ^[1] ; Victoria,Moreno-Manzano ^[6] ; Giuseppe,Lauria ^[7] ; Pierangelo,Metrangolo ^[8] ; Francesca Baldelli,Bombelli ^[9] ; Stefania,Marcuzzo ^[10]

作者单位： Neuroimmunology and Neuromuscular Diseases Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, Milan 20133, Italy. ^[1] Neuroimmunology and Neuromuscular Diseases Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, Milan 20133, Italy. Electronic address: eleonora.giagnorio@istituto-besta.it. ^[2] Neuroradiology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, Milan 20133, Italy; Laboratory of Supramolecular and Bio-Nanomaterials (SupraBioNano Lab), Department of Chemistry, Materials and Chemical Engineering, "Giulio Natta", Politecnico di Milano, Milan 20131, Italy. ^[3] Neuroalgology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, Milan 20133, Italy; PhD Program in Pharmacological Biomolecular Sciences, Experimental and Clinical, University of Milano, Via G.Balzaretti 9, Milan 20133, Italy. ^[4] Neuroimmunology and Neuromuscular Diseases Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, Milan 20133, Italy; Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 11/a, Parma 43124, Italy. ^[5] Neuronal and Tissue Regeneration Laboratory, Prince Felipe Research Center, Carrer d´Eduardo Primo Yúfera 3, Valencia 46012, Spain. ^[6] Neuroalgology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, Milan 20133, Italy; Department of Medical Biotechnology and Translational Medicine, University of Milano, Milan 20133, Italy. ^[7] Laboratory of Supramolecular and Bio-Nanomaterials (SupraBioNano Lab), Department of Chemistry, Materials and Chemical Engineering, "Giulio Natta", Politecnico di Milano, Milan 20131, Italy; Brains Lab, Joint Research Platform, Fondazione IRCCS Istituto Neurologico Carlo Besta-Politecnico di Milano, Via Celoria 11, 20133 Milan, Italy. ^[8] Laboratory of Supramolecular and Bio-Nanomaterials (SupraBioNano Lab), Department of Chemistry, Materials and Chemical Engineering, "Giulio Natta", Politecnico di Milano, Milan 20131, Italy. ^[9] Neuroimmunology and Neuromuscular Diseases Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, Milan 20133, Italy; Brains Lab, Joint Research Platform, Fondazione IRCCS Istituto Neurologico Carlo Besta-Politecnico di Milano, Via Celoria 11, 20133 Milan, Italy. Electronic address: stefania.marcuzzo@istituto-besta.it. ^[10]

关键词 Amyotrophic lateral sclerosis FM19G11 G93A-SOD1 mouse model Muscle Nanomedicine