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首页> Toxicology and applied pharmacology> Molecular docking, characterization, ADME/toxicity prediction, and anti-ulcer activity of new quercetin derivatives on indomethacin-induced gastric ulcer in mice.

Molecular docking, characterization, ADME/toxicity prediction, and anti-ulcer activity of new quercetin derivatives on indomethacin-induced gastric ulcer in mice.

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作者： Maha B,Salem ^[1] ; Abdulrahman M,Saleh ^[2] ; Sayed H,Seif El-Din ^[3] ; Safia,Samir ^[4] ; Olfat A,Hammam ^[5] ; Naglaa M,El-Lakkany ^[3]

作者单位： Pharmacology Department, Theodor Bilharz Research Institute, Giza, Egypt. Electronic address: m.salem@tbri.gov.eg. ^[1] Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of pharmacy (Boys), Al-Azhar University, Cairo, Egypt. ^[2] Pharmacology Department, Theodor Bilharz Research Institute, Giza, Egypt. ^[3] Biochemistry and Molecular Biology Department, Theodor Bilharz Research Institute, Giza, Egypt. ^[4] Pathology Department, Theodor Bilharz Research Institute, Giza, Egypt. ^[5]

关键词 Famotidine Gastric ulcer Indomethacin Molecular docking Quercetin TLR-4/MyD88/NF-κB signaling pathway

主题词人类(Humans);小鼠(Mice);动物(Animals);吲哚美辛(Indomethacin);胃溃疡(Stomach Ulcer);槲皮素(Quercetin);溃疡(Ulcer);NF-κB(NF-kappa B);髓样分化因子88(Myeloid Differentiation Factor 88);Toll样受体4(Toll-Like Receptor 4);胃黏膜(Gastric Mucosa)

DOI 10.1016/j.taap.2024.116880

PMID 38447874

发布时间 2024-03-20

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Toxicology and applied pharmacology

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