Simplex Lattice Design and Machine Learning Methods for the Optimization of Novel Microemulsion Systems to Enhance p-Coumaric Acid Oral Bioavailability: In Vitro and In Vivo Studies.

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作者： Nayera,Nasser ^[1] ; Rania M,Hathout ^[2] ; Hend,Abd-Allah ^[1] ; Omaima A,Sammour ^[1]

作者单位： Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, African Union Organization St., Cairo, 11566, Egypt. ^[1] Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, African Union Organization St., Cairo, 11566, Egypt. r_hathout@yahoo.com. ^[2]

关键词 in vivo cytotoxicity microemulsions p-coumaric acid re-dispersibility

主题词人类(Humans);Caco-2细胞(Caco-2 Cells);聚山梨醇酯类(Polysorbates);水(Water);香豆酸类(Coumaric Acids)

DOI 10.1208/s12249-024-02766-1

PMID 38448576

发布时间 2024-03-12

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