首页> Frontiers in pharmacology> Capsaicin ameliorate pulmonary fibrosis via antioxidant Nrf-2/ PPAR- γ pathway activation and inflammatory TGF-β1/ NF-κB/COX II pathway inhibition.

Capsaicin ameliorate pulmonary fibrosis via antioxidant Nrf-2/ PPAR- γ pathway activation and inflammatory TGF-β1/ NF-κB/COX II pathway inhibition.

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第一作者： Wesam H,Abdulaal

第一单位： Department of Biochemistry, King Fahd Medical Research Center, Faculty of Science, Cancer and Mutagenesis Unit, King Abdulaziz University, Jeddah, Saudi Arabia.;Mohamed Saeed Tamer Chair for Pharmaceutical Industries, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.;Center of Excellence for Drug Research and Pharmaceutical Industries, King Abdulaziz University, Jeddah, Saudi Arabia.

作者： Wesam H,Abdulaal ^[1] ; Hani Z,Asfour ^[2] ; Nawal,Helmi ^[3] ; Hadeel,Al Sadoun ^[4] ; Basmah,Eldakhakhny ^[5] ; Nabil A,Alhakamy ^[6] ; Hani Mohammed,Alqarni ^[7] ; Saeed Ali Mohammed,Alzahrani ^[7] ; Mohamed A,El-Moselhy ^[8] ; Sara S,Sharkawi ^[9] ; Esam Mohamed,Aboubakr ^[10]

作者单位： Department of Biochemistry, King Fahd Medical Research Center, Faculty of Science, Cancer and Mutagenesis Unit, King Abdulaziz University, Jeddah, Saudi Arabia.;Mohamed Saeed Tamer Chair for Pharmaceutical Industries, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.;Center of Excellence for Drug Research and Pharmaceutical Industries, King Abdulaziz University, Jeddah, Saudi Arabia. ^[1] Department of Medical Microbiology and Parasitology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia. ^[2] Department of Biochemistry, College of Science, University of Jeddah, Jeddah, Saudi Arabia. ^[3] Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia. ^[4] Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia. ^[5] Mohamed Saeed Tamer Chair for Pharmaceutical Industries, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.;Center of Excellence for Drug Research and Pharmaceutical Industries, King Abdulaziz University, Jeddah, Saudi Arabia.;Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia. ^[6] Center of Excellence for Drug Research and Pharmaceutical Industries, King Abdulaziz University, Jeddah, Saudi Arabia. ^[7] Clinical Pharmacy and Pharmacology Department, Ibn Sina National College for Medical Studies, Jeddah, Saudi Arabia.;Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, Minia, Egypt. ^[8] Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, Minia, Egypt. ^[9] Department of Pharmacology and Toxicology, Faculty of Pharmacy, South Valley University, Qena, Egypt. ^[10]

关键词 Capsaicin PPAR-γ Pirfenidone TGF-β1 TNF-α bleomycin pulmonary fibrosis

DOI 10.3389/fphar.2024.1333715

PMID 38449809

发布时间 2024-03-08

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准确一般字义偏差语意偏离译文作用小提交