Integrative Multimodal Metabolomics to Early Predict Cognitive Decline Among Amyloid Positive Community-Dwelling Older Adults.

导出 OA

翻译打印收藏纠错

第一作者： Marie,Tremblay-Franco

第一单位： Toxalim (Research Center in Food Toxicology), Toulouse University, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France.

作者： Marie,Tremblay-Franco ^[1] ; Cécile,Canlet ^[2] ; Audrey,Carriere ^[1] ; Jean,Nakhle ^[2] ; Anne,Galinier ^[3] ; Jean-Charles,Portais ^[3] ; Armelle,Yart ^[3] ; Cédric,Dray ^[4] ; Wan-Hsuan,Lu ^[3] ; Justine,Bertrand Michel ^[5] ; Sophie,Guyonnet ^[3] ; Yves,Rolland ^[3] ; Bruno,Vellas ^[6] ; Julien,Delrieu ^[7] ; Philippe de Souto,Barreto ^[8] ; Luc,Pénicaud ^[9] ; Louis,Casteilla ^[6] ; Isabelle,Ader ^[7] ; MAPT/DSA Group ^[6]

作者单位： Toxalim (Research Center in Food Toxicology), Toulouse University, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France. ^[1] Metatoul-AXIOM Platform, MetaboHUB, Toxalim, INRAE, Toulouse, France. ^[2] Institut RESTORE, UMR 1301 INSERM, 5070 CNRS, Université Paul Sabatier, Toulouse, France. ^[3] Institut Fédératif de Biologie, CHU Purpan, Toulouse, France. ^[4] MetaboHUB-MetaToul, National Infrastructure of Metabolomics and Fluxomics, Toulouse Biotechnology Institute, INSA de Toulouse INSA/CNRS 5504 - UMR INSA/INRA 792,Toulouse, France. ^[5] Gérontopole of Toulouse, Institute of Aging, Toulouse University Hospital (CHU Toulouse), Toulouse, France. ^[6] CERPOP UMR 1295, University of Toulouse III, INSERM, UPS, Toulouse, France. ^[7] Lipidomic, MetaboHUB-MetaToul, National Infrastructure of Metabolomics and Fluxomics, Toulouse, France. ^[8] I2MC, Université de Toulouse, Inserm, Université Toulouse III - Paul Sabatier (UPS), Toulouse, France (Biological Sciences Section). ^[9]

关键词 Alzheimer’s disease Bimodal metabolomics Cognitive decline Early prediction Metabolite signature Multiomics integrative method