DPP8/9 inhibition attenuates the TGF-β1-induced excessive deposition of extracellular matrix (ECM) in human mesangial cells via Smad and Akt signaling pathways.

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作者： Ke,Li ^[1] ; Yuzhan,Zhang ^[2] ; Weihao,Zhao ^[1] ; Rongrong,Wang ^[1] ; Yan,Li ^[1] ; Linting,Wei ^[1] ; Li,Wang ^[1] ; Xianghui,Chen ^[1] ; Zhao,Chen ^[1] ; Pengfei,Liu ^[3] ; Na,Nie ^[4] ; Xuefei,Tian ^[5] ; Rongguo,Fu ^[6]

作者单位： Department of Nephrology, The Second Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, Shaanxi 710004, China. ^[1] Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China. ^[2] National & Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China. ^[3] Department of Nephrology, Hanzhong Central Hospital, Hanzhong, Shaanxi 723000, China. ^[4] Section of Nephrology, Department of Internal Medicine, Yale University School of Medcine, New Haven, CT 06520, USA. Electronic address: 17602982521@163.com. ^[5] Department of Nephrology, The Second Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, Shaanxi 710004, China. Electronic address: fu_rongguo@sina.com. ^[6]

关键词 AKT DPP8/9 Extracellular matrix accumulation Mesangial cell TGF-β1/Smad