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Novel peptide-based oncolytic vaccine for enhancement of adaptive antitumor immune response via co-engagement of innate Fcγ and Fcα receptors.

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第一作者： Sara,Feola

第一单位： University of Helsinki Faculty of Pharmacy, Laboratory of Immunovirotherapy, Drug Research Program Helsinki, Uusimaa, FI, Helsinki, Finland.;Helsinki Institute of Life Science (HiLIFE), Fabianinkatu 33, University of Helsinki, 00710 Helsinki, Finland, Helsinki, Finland.;Translational Immunology Program (TRIMM), Faculty of Medicine Helsinki University, Helsinki, Finland.;Digital Precision Cancer Medicine Flagship (iCAN), University of Helsinki, Helsinki, Finland.

作者： Sara,Feola ^[1] ; Firas,Hamdan ^[1] ; Salvatore,Russo ^[1] ; Jacopo,Chiaro ^[1] ; Manlio,Fusciello ^[1] ; Michaela,Feodoroff ^[1] ; Gabriella,Antignani ^[1] ; Federica,D'Alessio ^[1] ; Riikka,Mölsä ^[1] ; Virpi,Stigzelius ^[1] ; Paolo,Bottega ^[1] ; Sari,Pesonen ^[2] ; Jeanette,Leusen ^[3] ; Mikaela,Grönholm ^[1] ; Vincenzo,Cerullo ^[4]

作者单位： University of Helsinki Faculty of Pharmacy, Laboratory of Immunovirotherapy, Drug Research Program Helsinki, Uusimaa, FI, Helsinki, Finland.;Helsinki Institute of Life Science (HiLIFE), Fabianinkatu 33, University of Helsinki, 00710 Helsinki, Finland, Helsinki, Finland.;Translational Immunology Program (TRIMM), Faculty of Medicine Helsinki University, Helsinki, Finland.;Digital Precision Cancer Medicine Flagship (iCAN), University of Helsinki, Helsinki, Finland. ^[1] Valo Therapeutics Oy, Helsinki, Finland. ^[2] Center for translational immunology, UMC Utrecht, Utrecht, The Netherlands. ^[3] University of Helsinki Faculty of Pharmacy, Laboratory of Immunovirotherapy, Drug Research Program Helsinki, Uusimaa, FI, Helsinki, Finland vincenzo.cerullo@helsinki.fi.;Helsinki Institute of Life Science (HiLIFE), Fabianinkatu 33, University of Helsinki, 00710 Helsinki, Finland, Helsinki, Finland.;Translational Immunology Program (TRIMM), Faculty of Medicine Helsinki University, Helsinki, Finland.;Digital Precision Cancer Medicine Flagship (iCAN), University of Helsinki, Helsinki, Finland.;Department of Molecular Medicine and Medical Biotechnology and CEINGE, Naples University Federico II, Naples, Italy. ^[4]

关键词 Adaptive Immunity Antigen Presentation Lymphocytes, Tumor-Infiltrating Neutrophil Infiltration Vaccination