Effect of biophysical properties of tumor extracellular matrix on intratumoral fate of nanoparticles: Implications on the design of nanomedicine.

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作者： Yachao,Tian ^[1] ; Tianfu,Cheng ^[2] ; Fuwei,Sun ^[2] ; Yaxin,Zhou ^[3] ; Chao,Yuan ^[4] ; Zengwang,Guo ^[5] ; Zhongjiang,Wang ^[6]

作者单位： College of Food Science, Northeast Agricultural University, Harbin, Heilongjiang 150030, China; Heilongjiang Guoru Biotechnology Co., Ltd., Xiangfang District, Harbin City 150030, China; School of Food Science and Engineering, Qilu University of Technology, Jinan, Shandong 250353, China. ^[1] College of Food Science, Northeast Agricultural University, Harbin, Heilongjiang 150030, China. ^[2] Key Laboratory of Functional Polymer Materials of Ministry of Education, State Key Laboratory of Medicinal Chemical Biology and Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China. ^[3] School of Food Science and Engineering, Qilu University of Technology, Jinan, Shandong 250353, China. ^[4] College of Food Science, Northeast Agricultural University, Harbin, Heilongjiang 150030, China. Electronic address: gzwname@neau.edu.cn. ^[5] College of Food Science, Northeast Agricultural University, Harbin, Heilongjiang 150030, China. Electronic address: wzjname@neau.edu.cn. ^[6]

关键词 Extracellular matrix Mechanical property Nanomedicine Tumor microenvironment Tumor penetration

主题词人类(Humans);钠米医学(Nanomedicine);肿瘤(Neoplasms);纳米粒子(Nanoparticles);药物释放系统(Drug Delivery Systems);细胞外基质(Extracellular Matrix);抗肿瘤药(Antineoplastic Agents)

DOI 10.1016/j.cis.2024.103124

PMID 38461766

发布时间 2024-04-15

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