Rapid and accurate SERS assay of disease-related nucleic acids based on isothermal cascade signal amplifications of CRISPR/Cas13a system and catalytic hairpin assembly.

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作者： Jingjing,Zhang ^[1] ; Zhilong,Chen ^[1] ; Huiming,Lv ^[1] ; Jing,Liang ^[1] ; Chenlong,Yan ^[1] ; Chunyuan,Song ^[2] ; Lianhui,Wang ^[3]

作者单位： State Key Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, Nanjing, 210023, China. ^[1] State Key Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, Nanjing, 210023, China; State Key Laboratory of Applied Optics, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun, 130033, China. Electronic address: iamcysong@njupt.edu.cn. ^[2] State Key Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, Nanjing, 210023, China. Electronic address: iamlhwang@njupt.edu.cn. ^[3]

关键词 CRISPR/Cas13a Cascade signal amplification Catalytic hairpin assembly Nucleic acids SERS

主题词核酸类(Nucleic Acids);RNA, 病毒(RNA, Viral);生物传感技术(Biosensing Techniques);生物学鉴定法(Biological Assay);核酸扩增技术(Nucleic Acid Amplification Techniques)

DOI 10.1016/j.bios.2024.116196

PMID 38467101

发布时间 2024-03-19

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